Article ID Journal Published Year Pages File Type
1231248 Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2013 8 Pages PDF
Abstract

The polyether antibiotic Lasalocid acid has been converted to its Mannich base derivative by a chemoselective one-pot reaction with formaldehyde and morpholine through the decarboxylation process. Spectroscopic studies of the structure of this new derivative have shown that in this ortho-phenol Mannich base the OH⋯N intarmolecular hydrogen bond is present. The compound forms complexes with Li+, Na+ and K+ cations of exclusively 1:1 stoichiometry. The structures of these complexes have been studied and visualized by semi-empirical calculation based on results of spectrometric and spectroscopic investigation. It is demonstrated that in contrast to Lasalocid acid the novel Mannich type derivative forms preferential complexes with Li+ cation.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► A new ortho-phenol Mannich base of Lasalocid was synthesized by chemoselective one-pot reaction. ► The compound obtained is a useful ligand for complexation of monovalent cations. ► Spectroscopic characterization of the ligand and prepared complexes is given. ► Semiempirical calculations of structures of the complexes studied are presented.

Related Topics
Physical Sciences and Engineering Chemistry Analytical Chemistry
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