Article ID Journal Published Year Pages File Type
1231413 Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2012 9 Pages PDF
Abstract

The novel azomethine, 3-((3,5-dimethylphenylimino)methyl)benzene-1,2-diol (HL) was synthesized and characterized by elemental analysis, FT-IR, 1H, 13C NMR spectroscopy and single crystal analysis. The title compound has been screened for its biological activities including enzymatic study, antibacterial, antifungal, cytotoxicity, antioxidant and interaction with CTDNA, and showed remarkable activities in each area of research. The titled compound interacts with DNA via two binding modes: intercalation and groove binding. In intercalation the compound inserts itself into the base pairs of DNA and the compound–DNA complex is stabilized by π–π stacking. Interaction via groove binding may be due to hydrogen bonding to bases, typically to N3 of adenine and O2 of thymine. The synthesized compound was also found to be an effective antioxidant of 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) and gives percent inhibition (%I) of 90.7 at a concentration level of 31.3 μg/mL.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Synthesis of a novel azomethine (HL), 3-((3,5-dimethylphenylimino)methyl)benzene-1,2-diol. ► Structural and spectroscopic characterization of HL. ► Biological activities of HL. ► Interaction with CTDNA.

Related Topics
Physical Sciences and Engineering Chemistry Analytical Chemistry
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