Investigation of the inclusion complex of β-cyclodextrin with mycophenolate mofetil

The acid–base equilibrium of mycophenolate mofetil is studied in the absence and presence of β-cyclodextrin (β-CD). The conditional acidity constants are obtained by rank annihilation factor analysis (RAFA) as a function of β-CD concentrations. Also the stability constants for inclusion complexes of β-CD with both acidic and basic forms are calculated. The conditional acidity constant decreases by increasing β-CD concentration. The calculated stability constants show that the acidic form of mycophenolate mofetil forms more stable inclusion complex (552 ± 7 M−1) than its basic anionic form (158 ± 2 M−1).

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlight► Interaction of mycophenolate mofetil with β-cyclodextrin has been studied. ► β-Cyclodextrin forms inclusion complex with mycophenolate mofetil. ► The acidity constant of complexed mycophenolate mofetil is different with free form. ► The acidity constant and formation constants for inclusion complexes were obtained.