Cisapride a green analytical reagent for rapid and sensitive determination of bromate in drinking water, bread and flour additives by oxidative coupling spectrophotometric methods

Green analytical methods using Cisapride (CPE) as green analytical reagent was investigated in this work. Rapid, simple, and sensitive spectrophotometric methods for the determination of bromate in water sample, bread and flour additives were developed. The proposed methods based on the oxidative coupling between phenoxazine and Cisapride in the presence of bromate to form red colored product with max at 520 nm. Phenoxazine and Cisapride and its reaction products were found to be environmentally friendly under the optimum experimental condition. The method obeys beers law in concentration range 0.11–4.00 g ml−1 and molar absorptivity 1.41 × 104 L mol−1 cm−1. All variables have been optimized and the presented reaction sequences were applied to the analysis of bromate in water, bread and flour additive samples. The performance of these method was evaluated in terms of Student’s t-test and variance ratio F-test to find out the significance of proposed methods over the reference method. The combination of pharmaceutical drugs reagents with low concentration create some unique green chemical analyses.

Graphical abstractWith the objective of utilizing the nontoxic chemicals which is a ‘control exercise’ for the formation of hazardous substances novel oxidative coupling reactions resulted using Cisapride (CPE) as green analytical spectrophotometric reagent.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► This is the first time that reported Cisapride as green analytical reagent. ► Sensitive and analytical reagent greener (pharmaceutical drugs). ► The amount two reagent used in the reaction low. ► In Yemen, green analytical chemistry is a trend towards fast and consistent growth.