| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1232147 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy | 2015 | 8 Pages |
•CoII/CoIII-(2-[{[2-(dimethylamino)ethyl]imino}methyl]-6-methoxyphenol).•Doubly azido-bridged Co trinuclear complex.•It is noteworthy that the CoIII atoms are diamagnetic in nature where as the central CoII atom behaves paramagnetically.•The complex decreases the cell population growth on human carcinoma cells.•Displays efficacy on the mycobacterial strains of human tuberculosis cells.
Doubly end-on azido-bridged mixed-valence trinuclear cobalt complex, [Co3(L)2(N3)6(CH3OH)2] (1) is afforded by employing a potential monoanionic tetradentate-N2O2 Schiff base precursor (2-[{[2-(dimethylamino)ethyl]imino}methyl]-6-methoxyphenol; HL). Single crystal X-ray structure reveals that in 1, the adjacent CoII and CoIII ions are linked by double end-on azido bridges and thus the full molecule is generated by the site symmetry of a crystallographic twofold rotation axis. Complex 1 is subjected on different spectral analysis such as IR, UV–vis, emission and EPR spectroscopy. On variable temperature magnetic study, we observe that during cooling, the χMT values decrease smoothly until 15 K and then reaches to the value 1.56 cm3 K mol−1 at 2 K. Complex 1 inhibits the cell growth on human lung carcinoma (A549 cells), human colorectal (COLO 205 and HT-29 cells), and human heptacellular (PLC5 cells) carcinoma cells. Complex 1 exhibits anti-mycobacterial activity and considerable efficacy on Mycobacterium tuberculosis H37Rv ATCC 27294 and H37Ra ATCC 25177 strains.
Graphical abstractDoubly azido-bridged trinuclear cobalt complex, [Co3(L)2(N3)6(CH3OH)2] (1) is synthesized where L = NMe2CH2CH2NCH(OH)(OMe)C6H3 in moderate yield. The Co atoms adopt a distorted octahedral geometry. Complex 1 inhibits the cell growth of human carcinoma cells and exhibits anti-mycobacterial activity on human tuberculosis cells.Figure optionsDownload full-size imageDownload as PowerPoint slide
