| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1232174 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy | 2010 | 7 Pages |
Abstract
The interactions of lorazepam, oxazepam and bromazepam with bovine serum albumin (BSA) were studied by fluorescence spectrometry. The Stern–Volmer quenching constants and corresponding thermodynamic parameters ΔH, ΔG and ΔS were calculated. The binding constants and the number of binding sites were also investigated. The distances between the donor (BSA) and the acceptors (benzodiazepines) were obtained according to fluorescence resonance energy transfer and conformational changes of BSA were observed from synchronous fluorescence spectra.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Roberta G. Machicote, María E. Pacheco, Liliana Bruzzone,