| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1232411 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy | 2015 | 8 Pages |
•Au nanoparticles functionalized monolithic column was designed for SERS.•The designed monolith was applied for on-column enrichment and SERS detection.•The SERS column provides high SERS sensitivity and good reproducibility.
A monolithic column functionalized with gold nanoparticles (GNPs) was designed to provide ultrasensitive detection with surface-enhanced Raman scattering (SERS). The monolithic column based on poly (glycidyl methacrylate-co-ethylene dimethacrylate) (GMA-co-EDMA) was served as the enrichment sorbent to concentrate GNPs and targets. We found that 60 nm GNPs-functionalized monolithic columns demonstrated the best SERS enhancement, and the lowest detectable concentration for PATP and CV could be achieved at 10−7 and 10−11 M, respectively. Moreover, the columns exhibit a good reproducibility in both spot-to-spot (∼10%) and batch-to-batch (∼15%). The SERS monolithic column with a high sensitivity and reproducibility has a great potential in the field-based rapid detection of targets in complex real-world samples.
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