| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1232654 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy | 2012 | 8 Pages |
A novel asymmetric ligand 2-(pyridine-2-yl)-1-H-imidazo[4,5-i]dibenzo[2,3-a:2′,3′-c]phenazine (pidbp) and its ruthenium complexes [Ru(L)2(pidbp)]2+ (L = bpy (2, 2′- bipyridine), phen (1, 10 – phenanthroline)), have been synthesized and characterized by elemental analysis, ES-MS, 1H NMR. Various methods support the conclusion that both Ru(II) complexes can intercalate into DNA base pairs. Complex [Ru(bpy)2(pidbp)]2+4 exhibits its DNA “molecular light switch” properties. Furthermore, the two complexes are efficient DNA-photocleavers under irradiation at 365 nm, and complex 5 exhibits a stronger DNA-photocleavage efficiency than complex 4. The mechanism of DNA cleavage is an oxidative process by generating singlet oxygen.
Graphical abstractA novel asymmetric ligand and its two Ru(II) complexes, [Ru(bpy)2(pidbp)]2+ and [Ru(phen)2(pidbp)]2+, have been synthesized and characterized. And [Ru(bpy)2(pidbp)]2+ is demonstrated to be the first example of Ru(II) complexes with asymmetric ligand, as DNA “molecular light switch”.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► A novel asymmetric ligand and its two Ru(II) complexes [Ru(L)2pidbp]2+have been synthesized and characterized. ► The DNA-binding results suggest that both complexes can bind to DNA by intercalation. ► [Ru(bpy)2(pidbp)]2+ is the first example of Ru(II) complexes with asymmetric ligand, as DNA “molecular light switch”. ► Both complexes can promote cleavage of pBR322 DNA under irradiation.
