Synthesis, spectroscopic, anticancer, antibacterial and antifungal studies of Ni(II) and Cu(II) complexes with hydrazine carboxamide, 2-[3-methyl-2-thienyl methylene]

•Synthesis and spectral characterizations of Schiff’s base ligand(L).•Preparation and spectral characterizations of Ni(II) and Cu(II) complexes with the ligand.•Antibacterial screening of ligand, and its Ni(II) and Cu(II) complexes against gram positive and gram negative bacteria.•Antifungal activity of ligand and its Ni(II) and Cu(II) complexes against some fungi.•Anticancer studies of ligand(L) and its Ni(II) and Cu(II) complexes against MCF 7.

Schiff’s base ligand(L) hydrazine carboxamide, 2-[3-methyl-2-thienyl methylene] and its metal complexes have been synthesized and characterized by elemental analysis, molar conductance, various spectroscopic techniques such as electronic, IR, 1H NMR, mass, EPR. Molar conductance of complexes in DMF solution corresponds to non-electrolyte. Complexes have general composition [M(L)2X2], where M = Ni(II) and Cu(II), X = Cl−, NO3−, CH3COO− and ½SO42−. On the basis of above spectral studies, an octahedral geometry has been assigned for Ni(II) complexes and tetragonal geometry for Cu(II) complexes except [Cu(L)2SO4] which possesses five coordinated trigonal bipyramidal geometry. These metal complexes were also tested for their anticancer, antibacterial and antifungal activities to assess their inhibition potential. Anticancer activity of ligand and its metal complexes were evaluated using SRB fluorometric assay and Adriamycin (ADR) was applied as positive control. Schiff’s base ligand and its metal complexes were screened for their antibacterial and antifungal activity against Escherichia coli, Bacillus cereus and Aspergillus niger, Aspergillus flavus, respectively. Kirby-Bauer single disk susceptibility test was used for antibacterial activity and well diffusion method for antifungal activity of the compounds on the used fungi.

Graphical abstractSchiff’s base ligand(L) hydrazine carboxamide, 2-[3-methyl-2-thienyl methylene] and its Ni(II) and Cu(II) metal complexes had been synthesized and characterized. These metal complexes were also tested for their antibacterial, antifungal and anticancer activities to assess their inhibiting potential.Figure optionsDownload full-size imageDownload as PowerPoint slide