Synthesis, spectroscopic characterization and antibacterial activity of antimony(III) bis(dialkyldithiocarbamato)alkyldithiocarbonates

Some mixed sulfur donor ligand complexes of antimony(III) of the general formula [(R2NCS2)]2SbS2COR′ where R = CH3, C2H5 and R′ = Me, Et, Prn, Pri, Bun and Bui have been synthesized by the reaction of antimony(III) bis(dialkyldithiocarbamate) chloride with potassium organodithiocarbonate in an equimolar ratio by stirring at room temperature in benzene/CS2 mixture. These complexes have been characterized by physicochemical [elemental analysis, melting points and molecular weight determinations] and spectral [UV, IR, Far-IR, NMR (1H and 13C), FAB+ mass and powder X-ray diffraction] studies. Free ligands and synthesized complexes have also been screened against different bacterial strains and results obtained made it desirable to delineate a comparison between free ligands, standard drug used and synthesized complexes.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Some mixed sulfur donor complexes of antimony(III) of the general formula [(R2NCS2)]2SbS2COR′ have been synthesized by the reaction of antimony(III) bis(dialkyldithiocarbamate) chloride with potassium organodithiocarbonate. ► Synthesized complexes have been characterized by different physicochemical and spectral studies in addition antibacterial activities have also been performed against different Gram- positive and Gram-negative bacterial strains. ► Spectral analysis consist of UV, IR, far-IR, NMR (1H and 13C), FAB+ mass and powder X-ray diffraction studies. ► FAB+ mass analysis is an important spectral study in order to identify complex in its basic form and powder XRD show that complexes are two phase and nanocrystalline. ► Synthesized complexes exhibit antibacterial properties against different human pathogenic bacterial strains. All above studies provides important structural information as well as biological importance of antimony complexes.