Article ID Journal Published Year Pages File Type
1233622 Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2009 4 Pages PDF
Abstract
Fluticasone propionate is a synthetic glucocorticoid with potent anti-inflammatory activity that has been used effectively in the treatment of chronic asthma. The present work reports a vibrational spectroscopic study of fluticasone propionate and gives proposed molecular assignments on the basis of ab initio calculations using BLYP density functional theory with a 6-31G* basis set and vibrational frequencies predicted within the quasi-harmonic approximation. Several spectral features and band intensities are explained. This study generated a library of information that can be employed to aid the process monitoring of fluticasone propionate.
Related Topics
Physical Sciences and Engineering Chemistry Analytical Chemistry
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