| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1234409 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy | 2012 | 5 Pages |
Most anticancer complexes are unable to differentiate between diseased and healthy cells, systemic toxicity and undesired side effects can result. In the current study, a PEG and RGD peptides functionalized fluorescent dye Rhodamine B isothiocyanate (RBITC) doped magnetic silica nanoparticle (MnFe3O4@SiO2-PEG-RGD), carrying a anticancer superparamagnetic Mn(II) complex, was synthesized and characterized using spectroscopic methods. The multifunctional nanoparticles (MnFe3O4@SiO2-PEG-RGD) can image HepG-2 cells and differentiate between HepG-2 and WRL-68 cells based on T1 MR imaging technology. The in vitro fluorescence image and inhibition assay on the proliferation of HeLa cells indicate that MnFe3O4@SiO2-PEG-RGD nanoparticles can effectively reach the tumor site, be internalized by endocytosis and then retain in cancer cells due to the retention effect of nanoparticles. This study demonstrated that a PEG and RGD peptides functionalized silica nanoparticle was a good carrier for the anticancer complexes, and the anticancer complexes loaded multifunctional nanoparticles could be developed as special agents in monitoring therapy of cancer.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► A fluorescent superparamagnetic silica nanoparticle was synthesized. ► The nanoparticles can image HepG-2 cells. ► The nanoparticles could differentiate HepG-2 from WRL-68 cells. ► It can be internalized by endocytosis.
