Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1234489 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy | 2008 | 7 Pages |
Abstract
Cyclic voltammetry and electron spin resonance techniques were used in the investigation of novel 3-alkoxy- and 3-hydroxy-1-[ω-(dialkylamino)alkyl]-5-nitroindazole derivatives. A self-protonation process involving the protonation of the nitro group was observed. The reactivity of the nitro-anion radical for these derivatives with glutathione, a biological relevant thiol, was also studied by cyclic voltammetry. These studies demonstrated that glutathione could react with radical species from 5-nitroindazole system. Also we demonstrated that nitro-anion radicals show three different patterns of delocalization where the indazole 1-lateral chain does not have major influence.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Jorge Rodríguez, Claudio Olea-Azar, German Barriga, Christian Folch, Alejandra Gerpe, Hugo Cerecetto, Mercedes González,