Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1234760 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy | 2013 | 10 Pages |
Copper(II), nickel(II), platinum(II) and palladium(II) complexes with 2-hydroxy-1-naphthaldehyde-N-methylpropanesulfonylhydrazone (nafpsmh) derived from propanesulfonic acid-1-methylhydrazide (psmh) were synthesized, their structure were identified, and antimicrobial activity of the compounds was screened against three Gram-positive and three Gram-negative bacteria. The results of antimicrobial studies indicate that Pt(II) and Pd(II) complexes showed the most activity against all bacteria. The crystal structure of 2-hydroxy-1-naphthaldehyde-N-methylpropanesulfonylhydrazone (nafpsmh) was also investigated by X-ray analysis. A series of Ni(II) sulfonyl hydrazone complexes (1–33) was synthesized and tested in vitro against Escherichia coli and Staphylococcus aureus. Their antimicrobial activities were used in the QSAR analysis. Four-parameter QSAR models revealed that nucleophilic reaction index for Ni and O atoms, and HOMO–LUMO energy gap play key roles in the antimicrobial activity.
Graphical abstractPlot of observed versus calculated pMIC values of training sets for: (a) E. coli and (b) S. aureusFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► New original sulfonylhydrazine and sulfonylhydrazone complexes were synthesized. ► New synthesized compounds were screened for their antibacterial activity. ► QSAR analysis was performed on Ni(II) sulfonylhdrazone complexes for E. coli and S. aureus.