| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1235732 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy | 2011 | 4 Pages |
The in vitro protein binding of retinoic acid isomers (isotretinoin and tretinoin) and the antihypertensive drugs (amlodipine and telmisartan) was studied by equilibrium dialysis method. In this study, free fraction of drugs and the % of binding of drugs in the mixture to bovine serum albumin (BSA) were calculated. The influence of retinoic acid isomers on the % of protein binding of telmisartan and amlodipine at physiological pH (7.4) and temperature (37 ± 0.5 °C) was also evaluated. The in vitro displacement interaction study of drugs telmisartan and amlodipine on retinoic acid isomers and also interaction of retinoic acid isomers on telmisartan and amlodipine were carried out.
Graphical abstractThe in vitro protein binding of retinoic acid isomers (isotretinoin and tretinoin) and the antihypertensive drugs (amlodipine and telmisartan) was studied by equilibrium dialysis method. In this study, free fraction of drugs and the % of binding of drugs in the mixture to bovine serum albumin (BSA) were calculated. The influence of retinoic acid isomers on the % of protein binding of telmisartan and amlodipine at physiological pH (7.4) and temperature (37 ± 0.5 °C) was also evaluated. The in vitro displacement interaction study of drugs telmisartan and amlodipine on retinoic acid isomers and also interaction of retinoic acid isomers on telmisartan and amlodipine were carried out.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► In vitro protein binding of retinoic acid isomers (isotretinoin and tretinoin) and antihypertensive drugs (amlodipine and telmisartan) studied. ► Drug–drug interactions play a vital role in plasma protein binding and therapeutic effect of the drugs. ► Telmisartan is preferred antihypertensive drug for concomitant therapy with retinoic acid isomers if advised. ► Among the isomers, isotretinoin preferred over tretinoin.
