Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1235915 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy | 2007 | 4 Pages |
Abstract
A new palladium(II) complex with methionine sulfoxide was synthesized and characterized by a set of chemical and spectroscopic techniques. Elemental and mass spectrometry analyses of the solid complex fit to the composition [Pd(C5H10NO3S)2]·H2O. 13C NMR, [1H–15N] NMR and infrared spectra indicate coordination of the amino acid to Pd(II) through the carboxylate and amino groups in a square planar geometry. The complex is soluble in water.Biological activity was evaluated by cytotoxic analysis using HeLa cells. Determination of cell death was assessed using a tetrazolium salt colorimetric assay, which reflects the cells viability. After incubation for 48 h, 20% of cell death was achieved at a concentration of 200 μmol L−1 of the complex.
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Authors
Pedro P. Corbi, Flávia Cagnin, Lilian P.B. Sabeh, Antonio C. Massabni, Claudio M. Costa-Neto,