Synthesis, characterization and antioxidant capacity of naringenin-oxime

The recognition of the benefits of polyphenolic antioxidants is eliciting increasing interest in the search for new polyphenolic derivatives with improved antioxidant activity. Since naringenin (4′,5,7-trihydroxyflavanone) (NG) is one of the most abundant citrus and grapefruit polyphenolics and flavanone oximes were used in the synthesis of anticancer and radioprotector compounds having antiradical activity, the corresponding oxime of NG, naringenin oxime (NG-Ox), was synthesized and investigated. The structure of NG-Ox was characterized by FT-IR, 1H NMR, elemental analysis, and the synthesized compound was screened for its antioxidant capacity by using the cupric reducing antioxidant capacity (CUPRAC) method. Trolox equivalent antioxidant capacity (TEAC) of NG-Ox was measured to be higher than that of the parent compound, NG. Other parameters of antioxidant activity (scavenging effects on OH, O2−, and H2O2) of NG-Ox were also determined.

Graphical abstractAntioxidant activity and synthesis of new naringenin-oxime (NG-Ox) are reported.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Naringenin oxime (NG-Ox) was characterized by various spectral techniques. ► NG-Ox screened for its antioxidant capacity and radical scavenging activity. ► NG-Ox showed higher antioxidant capacity as compared to pure naringenin (NG).