| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1236098 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy | 2012 | 5 Pages |
In the present work the feasibility of β-cyclodextrin in complexation was explored, as a tool for improving the solubility and biological ability of daidzein derivatives. A series of phosphorylated daidzein derivatives featuring different chain lengths were synthesized through a modified Atherton–Todd reaction and their inclusion complexes with βCD were prepared by coprecipitation method. The inclusion complexation behavior was studied by fluorescence, UV, FT-IR, MS and 1H NMR. The results showed that only phosphorylated daidzein derivative carrying small substituent group ((C2H5O)2PO) entered the cavity of βCD and formed 1:1 inclusion complex. The formation constant was 175 (mol/L)−1.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Phosphorylated daidzein derivatives featuring different chain lengths were synthesized. ► Their inclusion complexes with CD were prepared by coprecipitation method. ► The inclusion behavior was studied by fluorescence, UV, FT-IR, MS and NMR. ► The results showed that only daidzein derivative 3a entered the cavity of CD. ► 1:1 inclusion was formed and the formation constant was 175 (mol/L)−1.
