Antitubercular and fluorescence studies of copper(II) complexes with quinolone family member, ciprofloxacin

Four new mixed-ligand complexes of Cu(II) with ciprofloxacin (Cip) and uninegative bidentate ligands have been synthesized and characterized. The structure of mixed-ligand complexes was investigated using spectroscopic method, physicochemical and elemental analyses. The fluorescence spectra of complexes show red shift, which may be due to the chelation by the ligands to the metal ion. It enhances ligand ability to accept electrons and decreases the electron transition energy. Antimycobacterial screening of ligand and its copper compound against Mycobacterium tuberculosis shows clear enhancement in the antitubercular activity upon copper complexation.

Graphical abstractMixed ligand Cu(II) complexes with Cip and uninegative bidentate ligands characterized using spectroscopic method, physicochemical and elemental analyses. Results says that complexation enhances ligand ability to accept electrons and decreases the electron transition energy, also the enhancement in the antitubercular activity was observed.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► We examine that complexation of Cip with Cu(II) shows the antitubercular activity. ► Four new mixed-ligand complexes of Cu(II) with ciprofloxacin (Cip) and uninegative bidentate ligands have been synthesized and characterized. ► All the mixed ligand complexes show an effective antitubercular activity.