Synthesis, characterization, biological activities of dimethyltin(IV) complexes of Schiff bases with ONO-type donors

Four different dimethyltin(IV) complexes of Schiff bases derived from 2-amino-3-hydroxypyridine and different substituted salicylaldehydes have been synthesized. The compounds, with the general formula [Me2Sn(2-OArCHNC5H3NO)], where Ar = –C6H3(5-CH3) [Me2SnL1], –C6H3(5-NO2) [Me2SnL2], –C6H2(3,5-Cl2) [Me2SnL3], and –C6H2(3,5-I2) [Me2SnL4], were characterized by IR, NMR (1H and 13C), mass spectroscopy and elemental analysis. Me2SnL3 was also characterized by X-ray diffraction analysis and shows a fivefold C2NO2 coordination with distorted square pyramidal geometry. H3C–Sn–CH3 angles in the complexes were calculated using Lockhart's equations with the 1J(117/119Sn–13C) and 2J(117/119Sn–1H) values (from the 1H-NMR and 13C-NMR spectra). The in vitro antibacterial and antifungal activities of dimethyltin(IV) complexes were also investigated.