Novel homo-bimetallic complexes of [N10] macrocyclic ligand modified with tetrapeptide function: Biological activities, spectral and cyclic voltammetric studies

The bimetallic complexes [M2LCl4] (M = Cr, Co, Ni, Cu) prepared via metal template cyclization reactions were characterized by physico-chemical and spectroscopic methods. L is a 30-membered [N10] macrocycle with tetraamide functions bind metal ions through aza donors forming hexa-coordinate geometry. The perspective view and important structural parameters have been computed from the molecular model (MOPAC) method. The electrochemical studies indicate existence of quasi-reversible redox couples in solution. The metal complexes were screened (in vitro) against a few pathogenic fungi and bacteria to assess their growth inhibiting potential.