| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1237269 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy | 2009 | 5 Pages |
Abstract
The spectrophotometric and spectrofluorimetric studies revealed that hemoglobin (Hb) could interact with hypocrellin A, a photosensitizing drug used in photodynamic therapy. It was found that this kind of interaction can induce the conformational changes in Hb. In addition, based on fluorescence quenching titration and electron paramagnetic resonance spectroscopy results, the binding parameters, thermodynamic parameters are obtained. The quenching mechanism is also proposed.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Jiahong Zhou, Xiaohong Wu, Xiaotian Gu, Lin Zhou, Kaixi Song, Shaohua Wei, Yuying Feng, Jian Shen,