| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1237784 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy | 2008 | 4 Pages |
Abstract
Reaction of [RuCl3(dppb)H2O] (dppb = 1,4 bis(diphenylphospine)butane) with 2-benzoylpyridine thiosemicarbazone (H2Bz4DH) and its N(4)-methyl (H2Bz4M) and N(4)-phehyl (H2Bz4Ph) derivatives gave [RuCl(dppb)(H2Bz4DH)]Cl (1), [RuCl(dppb)(H2Bz4M)]Cl (2) and [RuCl(dppb)(H2Bz4Ph)]Cl (3). The cytotoxic activity of the studied compounds was tested against the MCF-7, TK-10 and UACC-62 human tumor cell lines. The precursor [RuCl3(dppb)H2O] exhibits cytocidal activity against the tree cell lines. H2BzDH, H2Bz4M, and [RuCl(dppb)(H2Bz4M)]Cl (2) show a selective cytocidal effect against the UACC-62 cell line which makes them the most promising compounds.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Angelica E. Graminha, Cláudia Rodrigues, Alzir A. Batista, Letícia R. Teixeira, Elaine S. Fagundes, Heloisa Beraldo,