Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1237860 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy | 2009 | 7 Pages |
Abstract
For the manufacture of dosage forms all ingredients must be reliably identified. In this paper, the suitability of FT-NIR spectroscopy to identify potassium sorbate, sodium starch glycollate, calcium ascorbate, calcium carbonate, candelilla wax, maltosextrin, monohydrated and anhydrous lactose inside USP vials was investigated. Differentiation between the anhydrous and monohydrated forms of lactose was found to be possible by studying the regions of the near-infrared spectrum corresponding to the combination and first overtone stretching frequencies of water. The results show unequivocally the potential of FT-NIR spectroscopy for rapid, in situ and non-destructive identification of pharmaceutical excipients.
Related Topics
Physical Sciences and Engineering
Chemistry
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Authors
Hassan Refat H. Ali, Howell G.M. Edwards, Ian J. Scowen,