Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1237912 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy | 2007 | 4 Pages |
Abstract
A derivative spectrophotometric method was developed for the assay of a ternary mixture of aspirin (ASP), paracetamol (PAR) and salicylic acid (SAL). The method is based on the use of the first and second derivatives of the ratio spectra and measurement at zero-crossing wavelengths. The ratio spectra were obtained by dividing the absorption spectrum of the mixture by that of one of the components. The concentration of the other components are then determined from their respective calibration curves treated similarly. The described method was applied for the determination of these combinations in synthetic mixtures and dosage forms. The results obtained were accurate and precise.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Fawzi A. El-Yazbi, Hassan H. Hammud, Sulaf A. Assi,