| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1238465 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy | 2007 | 5 Pages |
Abstract
Electron paramagnetic resonance (EPR) spectroscopy was used to investigate the gamma-radiation damage in the crystalline powder form of nine calcium channel blockers from the 1,4-dihydropyridine derivatives, which are in clinical use for treatment of arteria hypertension and ischemic heart disease. EPR studies have been carried out, showing the influence of irradiation and storage parameters on the nature and concentration of the free radicals trapped. EPR spectra of isardipine and felodipine showed single EPR line. EPR spectra of nifedipine, nisoldipine, nitrendipine, nimodipine, nicardipine and nilvadipine reveal a broad anisotropic signal of hyperfine interaction. No EPR signal was observed from amlodipine.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Marek Naskrent, Jadwiga Mielcarek,