Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1242902 | Talanta | 2013 | 6 Pages |
In the present work, sensitive and stable sandwiched electrochemical immunosensing strategies with graphene (Gr)/gold nanoparticles (GNP) composite as the immobilization platform and ferrocene (Fc) derivatives as labels were proposed. Under the optimal choice and the proposed immunosensing strategy, with 1,1′-ferrocenedicarboxylic acid label, the human IgG could be detected specifically with a low detection limit of 0.4 ng/mL and a wide linear dynamic range from 1 to 300 ng/mL. Meanwhile, the electrochemical behavior of three different ferrocene derivatives labels was studied.
► A sensitive electrochemical immunosensor was fabricated with new platform and label. ► Gold nanoparticles/graphene platform was fabricated with an easy electrodeposition method. ► 1,1′-ferrocenedicarboxylic acid was first introduced as the label. ► Three different ferrocene derivatives labels were compared and discussed.