Article ID Journal Published Year Pages File Type
1243156 Talanta 2008 6 Pages PDF
Abstract

The present work describes the development of an amperometric sensor based on hemin immobilized on a titanium oxide modified silica toward detection of artemisinin (ARN) in neutral medium at an applied potential of −0.5 V vs. Ag/AgCl. The sensor presented its best performance in 0.1 mol L−1 phosphate buffer solution, at pH 7.0. After optimizing the operational conditions, the sensor provided a linear response range for ARN reduction from 50 nmol L−1 to 1000 nmol L−1 with a sensitivity, detection and quantification limits of 24.66 A L mol−1, 15 nmol L−1 and 52 nmol L−1, respectively. The proposed sensor showed a stable response for at least 80 successive determinations. The repeatability of the measurements with the sensor and the preparation of a series of electrodes, evaluated in terms of relative standard deviation, were 4.1% and 5.0%, respectively, for n = 10. The developed sensor was applied for the determination of ARN in the crude extracts of A. vulgaris L and the average recovery for these samples is 101.4 (± 3.1)%.

Related Topics
Physical Sciences and Engineering Chemistry Analytical Chemistry
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