| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1243296 | Talanta | 2016 | 7 Pages |
•An cyt c ECL aptasensor was designed based on TiO2/CdS:Mn hybrids.•CdS:Mn QDs worked as the ECL emitter and aptamer linker.•The sensitivity was highly enhanced with using CdS:Mn QDs.•High specificity was achieved.•A wide linear range was achieved from 50 fM to 125 pM.
A novel electrochemiluminescence (ECL) aptasensor was proposed for ultrasensitive detection of cytochrome c (cyt c) using CdS:Mn quantum dot-modified TiO2 nanowires (NWs) as electrode. The Mn-doped CdS was deposited on the TiO2 NWs by successive ion layer adsorption and reaction (SILAR) as ECL emitter, on which thiol-modified aptamer of cyt c was attached via Cd–S bond. Due to the high photo-electrical transfer efficiency, the as-prepared aptasensor shows high selectivity and sensitivity towards cyt c with a detection limit of 9.5 fM and a linear range from 50 fM to 125 pM.
Graphical abstractA novel electrochemiluminescence (ECL) aptasensor was proposed for ultrasensitive detection of cytochrome c (cyt c) using CdS:Mn quantum dot-modified TiO2 nanowires (NWs) as electrode. The Mn-doped CdS was deposited on the TiO2 NWs by successive ion layer adsorption and reaction (SILAR) as ECL emitter, on which thiol-modified aptamer of cyt c was attached via Cd–S bond. Due to the high photo-electrical transfer efficiency, the as-prepared aptasensor shows high selectivity and sensitivity towards cyt c with a detection limit of 9.5 fM and a linear range from 50 fM to 125 pM.Figure optionsDownload full-size imageDownload as PowerPoint slide
