Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1243461 | Talanta | 2010 | 6 Pages |
Abstract
In this paper, we describe DNA electrochemical detection for genetically modified organism (GMO) based on multi-wall carbon nanotubes (MWCNTs)-doped polypyrrole (PPy). DNA hybridization is studied by quartz crystal microbalance (QCM) and electrochemical impedance spectroscopy (EIS). An increase in DNA complementary target concentration results in a decrease in the faradic charge transfer resistance (Rct) and signifying “signal-on” behavior of MWCNTs-PPy-DNA system. QCM and EIS data indicated that the electroanalytical MWCNTs-PPy films were highly sensitive (as low as 4 pM of target can be detected with QCM technique). In principle, this system can be suitable not only for DNA but also for protein biosensor construction.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Truong Thi Ngoc Lien, Tran Dai Lam, Vu Thi Hong An, Tran Vinh Hoang, Duong Tuan Quang, Dinh Quang Khieu, Toshifumi Tsukahara, Young Hoon Lee, Jong Seung Kim,