Article ID Journal Published Year Pages File Type
1243539 Talanta 2008 7 Pages PDF
Abstract

Voltammetric determination of adenosine and inosine has been carried out at single-wall carbon nanotubes (SWNTs) modified pyrolytic graphite electrode (PGE) at pH 7.2 using Osteryoung square wave voltammetry (OSWV). The modified electrode exhibits remarkable electrocatalytic properties towards adenosine and inosine oxidation with a peak potential of ∼1229 mV and 1348 mV, respectively. Linear calibration curves are obtained over the concentration range 0.5 μM to 1.0 mM in adenosine and 10 μM to 1.0 mM in inosine with sensitivity of 1.0 μA μM−1 and 1.9 μA μM−1 for adenosine and inosine respectively. The limit of detection for adenosine and inosine was found to be 0.51 × 10−7 M and 2.04 × 10−7 M, respectively. The proposed method was also used to estimate these compounds in human blood plasma and urine samples and the method was validated using HPLC.

Related Topics
Physical Sciences and Engineering Chemistry Analytical Chemistry
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