| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1243568 | Talanta | 2014 | 6 Pages |
•A rapid, simple and sensitive method for determination of carvedilol has been introduced.•ZnO nanocatalyst was synthesized by a mechanochemical method as a green route.•Carvedilol was determined at good linear working concentrations range and nanomolar detection limit.•The method has been successfully applied for determination of carvedilol in pharmaceuticals.
A simple, rapid and sensitive method was developed using ZnO nanoparticle (ZnO-NP) amplified flow-injection chemiluminescence to detect carvedilol, a non-cardioselective β-blocker. It has been found that carvedilol strongly inhibits the chemiluminescence of luminol–H2O2 catalyzed by ZnO-NPs. Under optimum conditions, a linear working range for carvedilol concentrations from 5×10−8 to 1.0×10−6 mol L−1 (r>0.9894, n=8) was obtained with a detection limit of 3.25×10−9 mol L−1. The relative standard deviation for 8 repetitive determinations was less than 2.9% and recoveries of 99% and 102% were obtained. ZnO-NPs were synthesized using a green mechanochemical route. Transmission electron microscopy and x-ray diffraction were used to characterize ZnO-NPs. The method was successfully applied to detect carvedilol in pharmaceutical formulations.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
