| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1243605 | Talanta | 2014 | 5 Pages |
•We propose rapid and accurate quantitative analysis of caffeine using standard addition strip-ESTASI-MS.•The standard addition strip-ESTASI-MS method was compared with classical standard addition methods for MS and LC.•The standard addition strip is low cost, single use and no cross-contamination takes place during the analysis.
Standard addition strips were prepared for the quantitative determination of caffeine in different beverages by electrostatic spray ionization mass spectrometry (ESTASI-MS). The gist of this approach is to dry spots of caffeine solutions with different concentrations on a polymer strip, then to deposit a drop of sample mixed with an internal standard, here theobromine on each spot and to measure the mass spectrometry signals of caffeine and theobromine by ESTASI-MS. This strip approach is very convenient and provides quantitative analyses as accurate as the classical standard addition method by MS or liquid chromatography.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
