Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1244003 | Talanta | 2007 | 5 Pages |
Abstract
A FIA-amperometric method for azithromycin determination was developed. A working glassy carbon electrode and a Ag/AgCl/NaCl (3 M) reference electrode were used. The determination is based on the electrochemical oxidation of the azithromycin at 0.9 V in Britton-Robinson buffer solution (pH 8.0). Due to the adsorption of the reaction products on the electrode surface, an effective cleaner cycle was implemented. By using the optimum chemical and FIA conditions, a concentration linear range of 1.0-10.0 mg Lâ1 and a detection limit (LOD) of 0.76 mg Lâ1 are obtained. The method was validated and satisfactorily applied to the determination of azithromycin in pharmaceutical formulations.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Miriam E. Palomeque, Patricia I. OrtÃz,