| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1244052 | Talanta | 2015 | 5 Pages |
•A taxol DNA biosensor was constructed.•DPV exhibits a linear dynamic range from 2.0×10−7 to 1.0×10−5 M.•This modified electrode was used for determination of taxol in real samples.
In this study a novel biosensor for determination of taxol is described. The interaction of taxol with salmon-sperm double-stranded DNA (ds-DNA) based on the decreasing of the oxidation signals of guanine and adenine bases was studied electrochemically with a pencil-graphite electrode (PGE) using a differential pulse voltammetry (DPV) method. The decreases in the intensity of the guanine and adenine oxidation signals after interaction with taxol were used as indicator signals for the sensitive determination of taxol. DPV exhibits a linear dynamic range of 2.0×10−7–1.0×10−5 M for taxol with a detection limit of 8.0×10−8 M. Finally, this modified electrode was used for determination of taxol in some real samples.
Graphical abstractA taxol DNA biosensor using ds-DNA modified pencil graphite electrode based on guanine and adenine signals was constructed.Figure optionsDownload full-size imageDownload as PowerPoint slide
