Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1245049 | Talanta | 2011 | 8 Pages |
Abstract
By means of a recent strategy based on accuracy profiles (β-expectation tolerance interval), the methods were successfully validated. β was fixed at 95% and the acceptability limits at ±15% as recommended by the FDA. The method was successfully validated for PTMD (29.6-586.54 ng/mL), analog 1 (74.23-742.3 ng/mL) and analog 2 (178.12-890.6 ng/mL). The first concentration level tested was considered as the LLOQ (lower limit of quantification) for PTMD and analog 1 whereas for analog 2, the LLOQ was not the first level tested and was raised to 178.12 ng/mL.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
S. Hambÿe, D. Stanicki, J.-M. Colet, E.M. Aliouat, J.J. Vanden Eynde, B. Blankert,