Article ID Journal Published Year Pages File Type
1245668 Talanta 2006 5 Pages PDF
Abstract

Two enantioselective, potentiometric membrane electrodes based on α- and γ-cyclodextrins were proposed for the assay of R-baclofen. The slopes of the electrodes were 59.50 and 51.00 mV/pR-baclofen for α- and γ-cyclodextrin-based electrodes, respectively. The detection limits of the proposed electrodes were 7 × 10−9 mol l−1 for α-cyclodextrin-based electrode and 1.44 × 10−10 mol l−1 for γ-cyclodextrin-based electrode. The enantioselectivity was determined over S-baclofen. The proposed electrodes can be employed for the assay of R-baclofen raw materials and its pharmaceutical formulation, Norton-Baclofen® tablets. The surfaces of the electrodes are stable and easily renewable by polishing on alumina paper.

Related Topics
Physical Sciences and Engineering Chemistry Analytical Chemistry
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