Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1245779 | Talanta | 2006 | 5 Pages |
Abstract
Based on the quenching of the fluorescence of CdSe quantum dots (QDs) by spironolactone, a simple, rapid and specific method for spironolactone determination was proposed. In the optimum conditions, spironolactone concentration versus quantum dot fluorescence gave a linear response with an excellent 0.997 correlation coefficient, between 2.5 and 700 mg/mL (6.0–1680 μmol/L) and the limit of detection (S/N = 3) was 0.2 μg/mL (0.48 μmol/L). The contents of spironolactone in pharmaceutical tablets were determined by the proposed method and the results agreed with the claimed values. The possible mechanism for the reaction was also discussed.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Jiangong Liang, Shan Huang, Danyun Zeng, Zhike He, Xinghu Ji, Xinping Ai, Hanxi Yang,