| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1246338 | Talanta | 2010 | 4 Pages |
Abstract
Emtricitabine (FTC) is an antiretroviral compound that inhibits the HIV-1 reverse transcriptase. For the quantification of FTC related substances, a liquid chromatography (LC) method coupled with ultraviolet (UV) detection was developed earlier in our laboratory. Several unknown compounds were detected during the analysis of a commercial sample. However, most of these impurities were not characterized. In this study, impurity profiling in a selected FTC sample was done using LC–mass spectrometry (MS). Due to the presence of a non-volatile buffer, a desalting procedure was carried out before sending the impurity into the MS. Totally, nine peaks were studied and most of them could be characterized.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Murali Pendela, Dunge Ashenafi Mamade, Jos Hoogmartens, Ann Van Schepdael, Erwin Adams,