Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1246381 | Talanta | 2010 | 6 Pages |
Abstract
A direct HPLC enantioseparation of three new chiral oxadiazoline derivatives endowed with potential MAO-B inhibitory activity was accomplished on the immobilised Chiralpak IA chiral stationary phase. Multi-mg amounts of enantiomers with high enantiomeric purity (ee ≥ 98%) were rapidly collected using pure dichloromethane as eluent. The absolute configuration and chiroptical properties of the enantiomers isolated at semipreparative scale were exhaustively determined.
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Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Maria Luisa Sanna, Elias Maccioni, Sara Vigo, Cristina Faggi, Roberto Cirilli,