Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1246632 | Talanta | 2010 | 10 Pages |
Electrochemical sensors demonstrating enantioselectivity to tryptophan enantiomers, with high selectivity and sensitivity, were fabricated by the use of a monolithic fiber of molecularly imprinted polymer-carbon composite. The recognition mechanism and performance of these sensors were evaluated by differential pulse anodic stripping voltammetry. The sensor imprinted for l-tryptophan not only discriminated the target from its analogues and other amino acids but also responded specifically in racemic mixture in aqueous, biological, and pharmaceutical samples. The binding kinetics of l-tryptophan was also established with the help of anodic stripping cyclic voltammetry and chronocoulometry. The detection limit for l-tryptophan was as low as 0.24 ng mL−1 (signal/noise = 3) which is appropriate for biomarking diseases, caused by an acute tryptophan-depletion, in clinical setting.