| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1248021 | TrAC Trends in Analytical Chemistry | 2013 | 9 Pages |
Abstract
•We highlight the use of mass spectrometry for the analysis of therapeutic mAbs.•We focus on mass spectrometry for characterization of increasingly complex samples.•Hot topics are sequence variances, biosimilars, bispecific mAbs, and mixtures of mAbs.•We report on new instrumentation to improve the analysis of therapeutic antibodies.
Mass spectrometry (MS) is emerging as an efficient method for the structural analysis of various new antibody-based therapeutic products. Here, we review the current trends and describe recent applications that highlight the use of MS to tackle the increasing complexity of monoclonal antibodies.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Sara Rosati, Natalie J. Thompson, Albert J.R. Heck, Sara Rosati, Natalie J. Thompson, Albert J.R. Heck,