Article ID Journal Published Year Pages File Type
1248449 TrAC Trends in Analytical Chemistry 2014 14 Pages PDF
Abstract

•The fourth generation coupled platform of mass spectrometry (MS) is described.•The recent applications of chip-MS in proteomics and cell analysis are reviewed.•Chip-MS is an emerging platform for biological analysis.

Microchip-mass spectrometry (chip-MS) has been emerging as an excellent analytical tool in the analysis of complex biological samples. The microchip can play an important role, as in cell culture and sample-preparation steps prior to mass spectral identification, which benefit from its ability to handle small sample quantities with the potential for high-throughput parallel analysis. We describe recent progress in chip-MS, including approaches that combined microchip devices with electrospray ionization and matrix-assisted laser desorption/ionization. We then review the main applications of chip-MS in proteomics and cell analysis in the past three years. We also look at the implications for the future of the field.

Related Topics
Physical Sciences and Engineering Chemistry Analytical Chemistry
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