Article ID Journal Published Year Pages File Type
1248620 TrAC Trends in Analytical Chemistry 2007 14 Pages PDF
Abstract

In pesticide residue analysis (PRA), as well as traditional quantitative analysis of target compounds – mainly pesticides in their parent form – there is now remarkable interest in screening pesticides in a comprehensive way, including not only common pesticides but also less common or relatively new pesticides (non-target) or unknown transformation products (unknowns).To address this interest, liquid chromatography coupled to mass spectrometry (LC-MS) with time-of-flight (TOF) analyzers (TOF-MS or QTOF-MS) is most suitable, taking into account accurate mass analysis, resolving power, enhanced selectivity and high sensitivity in full-scan acquisition mode.In this article, we discuss the main features and the advantages of LC-TOF-MS instruments for PRA in food – advantages and pitfalls of the instruments. We make a critical comparison, including examples, of the application of LC-TOF-MS to screening, identification and confirmation of target, non-target and unknown pesticides in foodstuffs.

Related Topics
Physical Sciences and Engineering Chemistry Analytical Chemistry
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