Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1248784 | TrAC Trends in Analytical Chemistry | 2007 | 19 Pages |
Abstract
The acid dissociation constant is an important physicochemical parameter of a substance, and knowledge of it is of fundamental importance in a wide range of applications and research areas. We present a critical review of published methods and approaches for the determination of acid dissociation constants, with a special emphasis on the pKa values of active pharmaceutical ingredients.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Sandra Babić, Alka J.M. Horvat, Dragana Mutavdžić Pavlović, Marija Kaštelan-Macan,