| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1248907 | TrAC Trends in Analytical Chemistry | 2006 | 8 Pages |
We review current and emerging capabilities of capillary electrophoresis (CE) as employed for metallodrug development. The application of gentle separation schemes and successful combinations with element-specific and molecule-specific mass-spectrometric detectors have increased the importance of CE as a tool in this area of biochemical speciation analysis.This article highlights recent progress of the method in assessing drug stability, separating metallodrugs and their metabolites, characterizing related metal-bioligand species, describing the kinetics and equilibrium of the corresponding metabolic processes, and analyzing biofluids.Finally, we discuss strategies for developing CE methods in metabolomic and proteomic analysis, centered on metal-based drugs so as ultimately to facilitate their discovery and preclinical investigation.
