Mesoporous silica-based materials for use in electrochemical enzyme nanobiosensors

Biology and medicine have seen great advancements in the development of enzyme nanobiosensors capable of characterizing and quantifying biomolecules.We provide an overview of mesoporous silica (MPS)-based enzyme nanobiosensors developed for biological and medical applications, and we describe significant advances in these technologies.We review progress in constructing high-performance electrochemical enzyme biosensors. We also discuss:•MCM-41 and SBA-15-modified and MPS composite electrodes for enzyme biosensing;•incorporation of biorecognition elements into MPS material electrodes for enzyme biosensing; and,•MCM-41 and SBA-15-supported electrocatalytic MPS-based electrochemical enzyme biosensors.

► The principles of enzyme-biosensor function are discussed. ► Recent advances in enzyme nanobiosensing are discussed. ► Electroanalytical application of mesoporous silica in enzyme-biosensor technology. ► Novel enzyme-immobilization methods are introduced.