| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1250550 | Vibrational Spectroscopy | 2011 | 7 Pages |
In this study, water penetration and the interaction between water and a pharmaceutical excipient in a tablet were investigated using near-infrared (NIR) spectroscopy and perturbation-correlation moving-window two-dimensional correlation spectroscopy (PCMW-2DCS). The penetration rate of water into a tablet was mainly dependent on the porosity of the tablet and was less dependent on the type of excipient. This behavior was well described by the Lucas–Washburn theory. The PCMW-2DCS technique revealed that there are two-staged interaction changes in NIR spectra of the water–powder interactions. The first and second changes corresponded to the water–solid interaction and the dissolution of the solid, respectively. The diffusion-controlled dissolution model by Nernst well explained these results.
