An efficient and simple synthesis of α-amino phosphonates as ‘drug like’ molecules catalyzed by silica-supported perchloric acid (HClO4–SiO2)

An efficient and direct protocol is described for the preparation of α-amino phosphonates derivatives by employing a multi-component, one-pot condensation reaction of aldehyde, amine and trialkyl phosphite in the presence of silica-supported perchloric acid (3 mol%) under solvent-free conditions. The thermal solvent-free green procedure offers advantages such as shorter reaction time, simple work-up, high yield, recovery and reusability of catalyst.