First Total Synthesis of Hyacinthacine A6 from the Protected Derivative of Polyhydroxylated Pyrrolidine

(1S,2R,3R,5R,7aR)-1,2-Dihydroxy-3-hydroxymethyl-5-methylpyrrolizidine(hyacinthacine A6, 1) was synthesized by Wittig's methodology via the reaction of aldehyde 6, prepared from the partially protected derivative of polyhydroxylated pyrrolidine, with appropriated ylides, followed by cyclization through the internal reductive amination process of the resulting α,β-unsaturated ketone 7, and total deprotection.